1zs4: Difference between revisions

Revision as of 04:08, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1zs4.png

Template:STRUCTURE 1zs4

Structure of bacteriophage lambda cII protein in complex with DNAStructure of bacteriophage lambda cII protein in complex with DNA

Template:ABSTRACT PUBMED 16039594

About this StructureAbout this Structure

1ZS4 is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of bacteriophage lambda cII and its DNA complex., Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA, Mol Cell. 2005 Jul 22;19(2):259-69. PMID:16039594

Page seeded by OCA on Tue Jul 29 04:08:50 2008

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OCA

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-'''Structure of bacteriophage lambda cII protein in complex with DNA'''
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-==Overview==
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-The tetrameric cII protein from bacteriophage lambda activates transcription from the phage promoters P(RE), P(I), and P(AQ) by binding to two direct repeats that flank the promoter -35 element. Here, we present the X-ray crystal structure of cII alone (2.8 A resolution) and in complex with its DNA operator from P(RE) (1.7 A resolution). The structures provide a basis for modeling of the activation complex with the RNA polymerase holoenzyme, and point to the key role for the RNA polymerase alpha subunit C-terminal domain (alphaCTD) in cII-dependent activation, which forms a bridge of protein/protein interactions between cII and the RNA polymerase sigma subunit. The model makes specific predictions for protein/protein interactions between cII and alphaCTD, and between alphaCTD and sigma, which are supported by previous genetic studies.
+The line below this paragraph, {{ABSTRACT_PUBMED_16039594}}, adds the Publication Abstract to the page
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 [[Category: Helix-turn-helix]]
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