1zpb: Difference between revisions

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{{STRUCTURE_1zpb|  PDB=1zpb  |  SCENE=  }}  
{{STRUCTURE_1zpb|  PDB=1zpb  |  SCENE=  }}  


'''Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide'''
===Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide===




==Overview==
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Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.
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{{ABSTRACT_PUBMED_16524727}}


==Disease==
==Disease==
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[[Category: Fxi]]
[[Category: Fxi]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:54:33 2008''
 
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