1zij: Difference between revisions

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{{STRUCTURE_1zij|  PDB=1zij  |  SCENE=  }}  
{{STRUCTURE_1zij|  PDB=1zij  |  SCENE=  }}  


'''GCN4-LEUCINE ZIPPER CORE MUTANT ASN16ABA IN THE TRIMERIC STATE'''
===GCN4-LEUCINE ZIPPER CORE MUTANT ASN16ABA IN THE TRIMERIC STATE===




==Overview==
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Each protein sequence generally adopts a single native fold, but the sequence features that confer structural uniqueness are not well understood. To define the basis for structural heterogeneity, we determined the high resolution X-ray crystal structures of a single GCN4 leucine-zipper mutant (Asn 16 to aminobutyric acid) in both dimeric and trimeric coiled-coil conformations. The mutant sequence is accommodated in two distinct structures by forming similarly-shaped packing surfaces with different sets of atoms. The trimer structure, in comparison to a previously-characterized trimeric mutant with substitutions in eight core residues, shows that the twist of individual helices and the helix-helix crossing angles can vary significantly to produce the most favoured packing arrangement.
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{{ABSTRACT_PUBMED_8946853}}


==About this Structure==
==About this Structure==
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[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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