1zh6: Difference between revisions

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{{STRUCTURE_1zh6|  PDB=1zh6  |  SCENE=  }}  
{{STRUCTURE_1zh6|  PDB=1zh6  |  SCENE=  }}  


'''Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine'''
===Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine===




==Overview==
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It has been recently shown that orthogonal tRNA/aminoacyl-tRNA synthetase pairs can be evolved to allow genetic incorporation of unnatural amino acids into proteins in both prokaryotes and eukaryotes. Here we describe the crystal structure of an evolved aminoacyl-tRNA synthetase that charges the unnatural amino acid p-acetylphenylalanine. Molecular recognition is due to altered hydrogen bonding and packing interactions with bound substrate that result from changes in both side-chain and backbone conformation.
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{{ABSTRACT_PUBMED_16248607}}


==About this Structure==
==About this Structure==
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[[Category: Trna synthetase]]
[[Category: Trna synthetase]]
[[Category: Unnatural amino acid]]
[[Category: Unnatural amino acid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:37:07 2008''
 
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