1z3x: Difference between revisions

Revision as of 20:19, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1z3x.png

Template:STRUCTURE 1z3x

Structure of Gun4 from Thermosynechococcus elongatusStructure of Gun4 from Thermosynechococcus elongatus

Template:ABSTRACT PUBMED 15909975

About this StructureAbout this Structure

1Z3X is a Single protein structure of sequence from Thermosynechococcus elongatus. Full crystallographic information is available from OCA.

ReferenceReference

Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis., Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN, Biochemistry. 2005 May 31;44(21):7603-12. PMID:15909975

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OCA

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-'''Structure of Gun4 from Thermosynechococcus elongatus'''
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-==Overview==
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-Gun4 has been implicated in a developmental signaling pathway between the chloroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated intermediate in the chlorophyll biosynthetic pathway. Here we present the crystal structure of Thermosynechococcus elongatus Gun4 at 1.5 A, describe the binding affinities of Gun4 for substrate and product porphyrin molecules, and identify a likely (Mg)P(IX) binding site on the protein. Kinetic analyses show that Gun4 dramatically increases the efficiency of transformation of porphyrin substrate to metalloporphyrin product and that it also reduces the threshold Mg2+ concentration required for activity at low porphyrin concentration. Gun4 therefore controls magnesium chelatase at physiologically significant Mg2+ concentrations and likely acts as a molecular switch in vivo so that in its absence magnesium chelatase is inactive. This mechanism could allow Gun4 to mediate magnesium protoporphyrin levels both for chlorophyll biosynthesis and for signaling to the nucleus.
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 [[Category: Schubert, H L.]]
 [[Category: Transferase activator]]
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