1yz9: Difference between revisions

Revision as of 13:34, 27 July 2008

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File:1yz9.png

Template:STRUCTURE 1yz9

Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom ResolutionCrystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution

Template:ABSTRACT PUBMED 16216575

About this StructureAbout this Structure

1YZ9 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

ReferenceReference

Intermediate states of ribonuclease III in complex with double-stranded RNA., Gan J, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X, Structure. 2005 Oct;13(10):1435-42. PMID:16216575

Page seeded by OCA on Sun Jul 27 13:34:21 2008

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-[[Image:1yz9.gif|left|200px]]
+{{Seed}}
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 {{STRUCTURE_1yz9|  PDB=1yz9  |  SCENE=  }}
-'''Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution'''
+===Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution===
-==Overview==
+<!--
-Bacterial ribonuclease III (RNase III) can affect RNA structure and gene expression in either of two ways: as a processing enzyme that cleaves double-stranded (ds) RNA, or as a binding protein that binds but does not cleave dsRNA. We previously proposed a model of the catalytic complex of RNase III with dsRNA based on three crystal structures, including the endonuclease domain of RNase III with and without bound metal ions and a dsRNA binding protein complexed with dsRNA. We also reported a noncatalytic assembly observed in the crystal structure of an RNase III mutant, which binds but does not cleave dsRNA, complexed with dsRNA. We hypothesize that the RNase III*dsRNA complex can exist in two functional forms, a catalytic complex and a noncatalytic assembly, and that in between the two forms there may be intermediate states. Here, we present four crystal structures of RNase III complexed with dsRNA, representing possible intermediates.
+The line below this paragraph, {{ABSTRACT_PUBMED_16216575}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16216575 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_16216575}}
 ==About this Structure==
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 [[Category: Ribonuclease iii]]
 [[Category: Rna interference]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:34:21 2008''