1yw2: Difference between revisions

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[[Image:1yw2.gif|left|200px]]
{{Seed}}
[[Image:1yw2.png|left|200px]]


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{{STRUCTURE_1yw2|  PDB=1yw2  |  SCENE=  }}  
{{STRUCTURE_1yw2|  PDB=1yw2  |  SCENE=  }}  


'''Mutated Mus Musculus P38 Kinase (mP38)'''
===Mutated Mus Musculus P38 Kinase (mP38)===




==Overview==
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4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production.
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{{ABSTRACT_PUBMED_15837333}}


==About this Structure==
==About this Structure==
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[[Category: Xu, S C.]]
[[Category: Xu, S C.]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:51:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:28:34 2008''

Revision as of 11:28, 28 July 2008

File:1yw2.png

Template:STRUCTURE 1yw2

Mutated Mus Musculus P38 Kinase (mP38)Mutated Mus Musculus P38 Kinase (mP38)

Template:ABSTRACT PUBMED 15837333

About this StructureAbout this Structure

1YW2 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production., Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2399-403. PMID:15837333

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