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| [[Image:1yu1.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1yu1| PDB=1yu1 | SCENE= }} | | {{STRUCTURE_1yu1| PDB=1yu1 | SCENE= }} |
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| '''Major Tropism Determinant P3c Variant'''
| | ===Major Tropism Determinant P3c Variant=== |
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| ==Overview==
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| Only few instances are known of protein folds that tolerate massive sequence variation for the sake of binding diversity. The most extensively characterized is the immunoglobulin fold. We now add to this the C-type lectin (CLec) fold, as found in the major tropism determinant (Mtd), a retroelement-encoded receptor-binding protein of Bordetella bacteriophage. Variation in Mtd, with its approximately 10(13) possible sequences, enables phage adaptation to Bordetella spp. Mtd is an intertwined, pyramid-shaped trimer, with variable residues organized by its CLec fold into discrete receptor-binding sites. The CLec fold provides a highly static scaffold for combinatorial display of variable residues, probably reflecting a different evolutionary solution for balancing diversity against stability from that in the immunoglobulin fold. Mtd variants are biased toward the receptor pertactin, and there is evidence that the CLec fold is used broadly for sequence variation by related retroelements.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16170324}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16170324 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16170324}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Diversity-generating retroelement]] | | [[Category: Diversity-generating retroelement]] |
| [[Category: Variability]] | | [[Category: Variability]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:47:18 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:24:04 2008'' |