1ypq: Difference between revisions

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-[[Image:1ypq.gif|left|200px]]
+{{Seed}}
+[[Image:1ypq.png|left|200px]]
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 {{STRUCTURE_1ypq|  PDB=1ypq  |  SCENE=  }}
-'''Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex'''
+===Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex===
-==Overview==
+<!--
-The lectin-like oxidized low density lipoprotein receptor-1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein by vascular endothelial cells. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis. The 1.4 angstrom crystal structure of the extracellular C-type lectin-like domain of human Lox-1 reveals a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that extends through the entire molecule, and an electrostatically neutral patch of 12 charged residues that resides next to the tunnel at each opening. Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands.
+The line below this paragraph, {{ABSTRACT_PUBMED_15695803}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15695803 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15695803}}
 ==About this Structure==
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 [[Category: Nk cell receptor]]
 [[Category: Oxidized low density lipoprotein receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:37:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:47:11 2008''