1yhs: Difference between revisions

Revision as of 12:21, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1yhs.png

Template:STRUCTURE 1yhs

Crystal structure of Pim-1 bound to staurosporineCrystal structure of Pim-1 bound to staurosporine

Template:ABSTRACT PUBMED 15657054

About this StructureAbout this Structure

1YHS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002., Jacobs MD, Black J, Futer O, Swenson L, Hare B, Fleming M, Saxena K, J Biol Chem. 2005 Apr 8;280(14):13728-34. Epub 2005 Jan 17. PMID:15657054

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1yhs.gif|left|200px]]
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 {{STRUCTURE_1yhs|  PDB=1yhs  |  SCENE=  }}
-'''Crystal structure of Pim-1 bound to staurosporine'''
+===Crystal structure of Pim-1 bound to staurosporine===
-==Overview==
+<!--
-Pim-1 is an oncogene-encoded serine/threonine kinase primarily expressed in hematopoietic and germ cell lines. Pim-1 kinase was originally identified in Maloney murine leukemia virus-induced T-cell lymphomas and is associated with multiple cellular functions such as proliferation, survival, differentiation, apoptosis, and tumorigenesis (Wang, Z., Bhattacharya, N., Weaver, M., Petersen, K., Meyer, M., Gapter, L., and Magnuson, N. S. (2001) J. Vet. Sci. 2, 167-179). The crystal structures of Pim-1 complexed with staurosporine and adenosine were determined. Although a typical two-domain serine/threonine protein kinase fold is observed, the inter-domain hinge region is unusual in both sequence and conformation; a two-residue insertion causes the hinge to bulge away from the ATP-binding pocket, and a proline residue in the hinge removes a conserved main chain hydrogen bond donor. Without this hydrogen bond, van der Waals interactions with the hinge serve to position the ligand. The hinge region of Pim-1 resembles that of phosphatidylinositol 3-kinase more closely than it does other protein kinases. Although the phosphatidylinositol 3-kinase inhibitor LY294002 also inhibits Pim-1, the structure of the LY294002.Pim-1 complex reveals a new binding mode that may be general for Ser/Thr kinases.
+The line below this paragraph, {{ABSTRACT_PUBMED_15657054}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15657054}}
 ==About this Structure==
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 [[Category: Protein kinase]]
 [[Category: Proto-oncogene]]
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