2b52: Difference between revisions
New page: left|200px<br /> <applet load="2b52" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b52, resolution 1.88Å" /> '''Human cyclin depend... |
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[[Image:2b52.gif|left|200px]]<br /> | [[Image:2b52.gif|left|200px]]<br /><applet load="2b52" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2b52" size=" | |||
caption="2b52, resolution 1.88Å" /> | caption="2b52, resolution 1.88Å" /> | ||
'''Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562'''<br /> | '''Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562'''<br /> | ||
==Overview== | ==Overview== | ||
New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have | New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523. | ||
==About this Structure== | ==About this Structure== | ||
2B52 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with D42 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | 2B52 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=D42:'>D42</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B52 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: protein kinase]] | [[Category: protein kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:14 2008'' | ||
