1xa2: Difference between revisions

Revision as of 09:50, 29 July 2008

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Template:STRUCTURE 1xa2

Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA).d(TGCGCG) in two crystal formsCobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA).d(TGCGCG) in two crystal forms

Template:ABSTRACT PUBMED 15534365

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA)*d(TGCGCG) in two crystal forms., Thiyagarajan S, Rajan SS, Gautham N, Nucleic Acids Res. 2004 Nov 8;32(19):5945-53. Print 2004. PMID:15534365

Structure of d(TGCGCG).d(CGCGCA) in two crystal forms: effect of sequence and crystal packing in Z-DNA., Thiyagarajan S, Rajan SS, Gautham N, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1125-31. Epub 2005, Jul 20. PMID:16041078

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-'''Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA).d(TGCGCG) in two crystal forms'''
+===Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA).d(TGCGCG) in two crystal forms===
-==Overview==
+<!--
-We report here the crystal structure of the DNA hexamer duplex d(CGCGCA)*d(TGCGCG) at 1.71 A resolution. The crystals, in orthorhombic space group, were grown in the presence of cobalt hexammine, a known inducer of the left-handed Z form of DNA. The interaction of this ion with the DNA helix results in a change of the adenine base from the common amino tautomeric form to the imino tautomer. Consequently the A:T base pair is disrupted from the normal Watson-Crick base pairing to a 'wobble' like base pairing. This change is accommodated easily within the helix, and the helical parameters are those expected for Z-DNA. When the cobalt hexammine concentration is decreased slightly in the crystallization conditions, the duplex crystallizes in a different, hexagonal space group, with two hexamer duplexes in the asymmetric unit. One of these is situated on a crystallographic 6-fold screw axis, leading to disorder. The tautomeric shift is not observed in this space group. We show that the change in inter-helix interactions that lead to the two different space groups probably arise from the small decrease in ion concentration, and consequently disordered positions for the ion.
+The line below this paragraph, {{ABSTRACT_PUBMED_15534365}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15534365}}
 ==About this Structure==
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 ==Reference==
 Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA)*d(TGCGCG) in two crystal forms., Thiyagarajan S, Rajan SS, Gautham N, Nucleic Acids Res. 2004 Nov 8;32(19):5945-53. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15534365 15534365]
+Structure of d(TGCGCG).d(CGCGCA) in two crystal forms: effect of sequence and crystal packing in Z-DNA., Thiyagarajan S, Rajan SS, Gautham N, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1125-31. Epub 2005, Jul 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16041078 16041078]
 [[Category: Gautham, N.]]
 [[Category: Rajan, S S.]]
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 [[Category: Double helix]]
 [[Category: Z-dna]]
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