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| [[Image:1x71.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1x71| PDB=1x71 | SCENE= }} | | {{STRUCTURE_1x71| PDB=1x71 | SCENE= }} |
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| '''Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with TRENCAM-3,2-HOPO, a cepabactin analogue'''
| | ===Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with TRENCAM-3,2-HOPO, a cepabactin analogue=== |
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| ==Overview==
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| Siderocalin, a member of the lipocalin family of binding proteins, is found in neutrophil granules, uterine secretions, and at markedly elevated levels in serum and synovium during bacterial infection; it is also secreted from epithelial cells in response to inflammation or tumorigenesis. Identification of high-affinity ligands, bacterial catecholate-type siderophores (such as enterochelin), suggested a possible function for siderocalin: an antibacterial agent, complementing the general antimicrobial innate immune system iron-depletion strategy, sequestering iron as ferric siderophore complexes. Supporting this hypothesis, siderocalin is a potent bacteriostatic agent in vitro under iron-limiting conditions and, when knocked out, renders mice remarkably susceptible to bacterial infection. Here we show that siderocalin also binds soluble siderophores of mycobacteria, including M. tuberculosis: carboxymycobactins. Siderocalin employs a degenerate recognition mechanism to cross react with these dissimilar types of siderophores, broadening the potential utility of this innate immune defense.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15642259}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15642259 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15642259}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Lipocalin]] | | [[Category: Lipocalin]] |
| [[Category: Siderophore]] | | [[Category: Siderophore]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:38:54 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:32:02 2008'' |