1x0f: Difference between revisions

Revision as of 18:03, 27 July 2008

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File:1x0f.png

Template:STRUCTURE 1x0f

Complex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNAComplex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNA

Template:ABSTRACT PUBMED 15734733

About this StructureAbout this Structure

1X0F is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D., Enokizono Y, Konishi Y, Nagata K, Ouhashi K, Uesugi S, Ishikawa F, Katahira M, J Biol Chem. 2005 May 13;280(19):18862-70. Epub 2005 Feb 24. PMID:15734733

Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA., Katahira M, Miyanoiri Y, Enokizono Y, Matsuda G, Nagata T, Ishikawa F, Uesugi S, J Mol Biol. 2001 Aug 31;311(5):973-88. PMID:11531333

Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0., Nagata T, Kurihara Y, Matsuda G, Saeki J, Kohno T, Yanagida Y, Ishikawa F, Uesugi S, Katahira M, J Mol Biol. 1999 Mar 26;287(2):221-37. PMID:10080887

Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n., Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR, Mol Cell Biol. 1993 Jul;13(7):4301-10. PMID:8321232

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OCA

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-[[Image:1x0f.gif|left|200px]]
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-'''Complex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNA'''
+===Complex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNA===
-==Overview==
+<!--
-Heterogeneous nuclear ribonucleoprotein D, also known as AUF1, has two DNA/RNA-binding domains, each of which can specifically bind to single-stranded d(TTAGGG)n, the human telomeric repeat. Here, the structure of the C-terminal-binding domain (BD2) complexed with single-stranded d(TTAGGG) determined by NMR is presented. The structure has revealed that each residue of the d(TAG) segment is recognized by BD2 in a base-specific manner. The interactions deduced from the structure have been confirmed by gel retardation experiments with mutant BD2 and DNA. It is known that single-stranded DNA with the telomeric repeat tends to form a quadruplex and that the quadruplex has an inhibitory effect on telomere elongation by telomerase. This time it is revealed that BD2 unfolds the quadruplex of such DNA upon binding. Moreover, the effect of BD2 on the elongation by telomerase was examined in vitro. These results suggest the possible involvement of heterogeneous nuclear ribonucleoprotein D in maintenance of the telomere 3'-overhang either through protection of a single-stranded DNA or destabilization of the potentially deleterious quadruplex structure for the elongation by telomerase.
+The line below this paragraph, {{ABSTRACT_PUBMED_15734733}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15734733 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15734733}}
 ==About this Structure==
-X0F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X0F OCA].
+X0F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X0F OCA].
 ==Reference==
 Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D., Enokizono Y, Konishi Y, Nagata K, Ouhashi K, Uesugi S, Ishikawa F, Katahira M, J Biol Chem. 2005 May 13;280(19):18862-70. Epub 2005 Feb 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734733 15734733]
+Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA., Katahira M, Miyanoiri Y, Enokizono Y, Matsuda G, Nagata T, Ishikawa F, Uesugi S, J Mol Biol. 2001 Aug 31;311(5):973-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11531333 11531333]
+Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0., Nagata T, Kurihara Y, Matsuda G, Saeki J, Kohno T, Yanagida Y, Ishikawa F, Uesugi S, Katahira M, J Mol Biol. 1999 Mar 26;287(2):221-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10080887 10080887]
+Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n., Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR, Mol Cell Biol. 1993 Jul;13(7):4301-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8321232 8321232]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
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 [[Category: Structural genomic]]
 [[Category: Telomere]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:22:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:03:04 2008''