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| {{STRUCTURE_1wcd| PDB=1wcd | SCENE= }} | | {{STRUCTURE_1wcd| PDB=1wcd | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF IBDV T1 VIRUS-LIKE PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION'''
| | ===CRYSTAL STRUCTURE OF IBDV T1 VIRUS-LIKE PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION=== |
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| ==Overview==
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| Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm of the target cell. Birnaviruses are unique among dsRNA viruses as they have a single T = 13 icosahedral shell, lacking the characteristic inner capsid observed in the others. We determined the crystal structures of the T = 1 subviral particle (260 angstroms in diameter) and of the T = 13 intact virus particle (700 angstroms in diameter) of an avian birnavirus to 3 angstroms and 7 angstroms resolution, respectively. Our results show that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13 capsid protein of members of the Reoviridae family of dsRNA viruses. Together, these results provide important insights into the multiple functions of the birnavirus capsid and reveal unexpected structural relationships among icosahedral viruses.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15797378}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15797378 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15797378}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Non-enveloped icosahedral viruse]] | | [[Category: Non-enveloped icosahedral viruse]] |
| [[Category: Transcriptase machinery]] | | [[Category: Transcriptase machinery]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:27:28 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:22:59 2008'' |