1zmj: Difference between revisions
New page: left|200px<br /> <applet load="1zmj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zmj, resolution 2.00Å" /> '''Crystal Structure o... |
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[[Image:1zmj.gif|left|200px]]<br /> | [[Image:1zmj.gif|left|200px]]<br /><applet load="1zmj" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1zmj" size=" | |||
caption="1zmj, resolution 2.00Å" /> | caption="1zmj, resolution 2.00Å" /> | ||
'''Crystal Structure of the Catalytic Domain of Factor XI in complex with 4-(guanidinomethyl)-phenylboronic acid'''<br /> | '''Crystal Structure of the Catalytic Domain of Factor XI in complex with 4-(guanidinomethyl)-phenylboronic acid'''<br /> | ||
==Overview== | ==Overview== | ||
A series of functionalized aryl boronic acids were synthesized and | A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1ZMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, HDB and TRS as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | 1ZMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=HDB:'>HDB</scene> and <scene name='pdbligand=TRS:'>TRS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMJ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Babine, R | [[Category: Babine, R E.]] | ||
[[Category: Bibbins, F.]] | [[Category: Bibbins, F.]] | ||
[[Category: Gorga, J | [[Category: Gorga, J C.]] | ||
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
[[Category: Lazarova, T | [[Category: Lazarova, T I.]] | ||
[[Category: Meyers, H | [[Category: Meyers, H V.]] | ||
[[Category: Rynkiewicz, M | [[Category: Rynkiewicz, M J.]] | ||
[[Category: Strickler, J | [[Category: Strickler, J E.]] | ||
[[Category: HDB]] | [[Category: HDB]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:07 2008'' | ||
