1wac: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1wac.gif|left|200px]]
+{{Seed}}
+[[Image:1wac.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1wac|  PDB=1wac  |  SCENE=  }}
-'''BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE'''
+===BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE===
-==Overview==
+<!--
-The RNA-dependent RNA polymerase of the double-stranded RNA bacteriophage phi6 is capable of primer-independent initiation, as are many RNA polymerases. The structure of this polymerase revealed an initiation platform, composed of a loop in the C-terminal domain (QYKW, aa 629-632), that was essential for de novo initiation. A similar element has been identified in hepatitis C virus RNA-dependent RNA polymerase. Biochemical studies have addressed the role of this platform, revealing that a mutant version can utilize a back-priming initiation mechanism, where the 3' terminus of the template adopts a hairpin-like conformation. Here, the mechanism of back-primed initiation is studied further by biochemical and structural methods.
+The line below this paragraph, {{ABSTRACT_PUBMED_15659773}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15659773 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15659773}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Phi6 rna-dependent rna polymerase]]
 [[Category: Transcription]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:22:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:37:14 2008''