1vid: Difference between revisions

Revision as of 23:39, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1vid.png

Template:STRUCTURE 1vid

CATECHOL O-METHYLTRANSFERASECATECHOL O-METHYLTRANSFERASE

Template:ABSTRACT PUBMED 8127373

About this StructureAbout this Structure

1VID is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of catechol O-methyltransferase., Vidgren J, Svensson LA, Liljas A, Nature. 1994 Mar 24;368(6469):354-8. PMID:8127373

Page seeded by OCA on Mon Jul 28 23:39:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1vid.gif|left|200px]]
+{{Seed}}
+[[Image:1vid.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1vid|  PDB=1vid  |  SCENE=  }}
-'''CATECHOL O-METHYLTRANSFERASE'''
+===CATECHOL O-METHYLTRANSFERASE===
-==Overview==
+<!--
-Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols. COMT also inactivates catechol-type compounds such as L-DOPA. With selective inhibitors of COMT in combination with L-DOPA, a new principle has been realized in the therapy of Parkinson's disease. Here we solve the atomic structure of COMT to 2.0 A resolution, which provides new insights into the mechanism of the methyl transfer reaction. The co-enzyme-binding domain is strikingly similar to that of an AdoMet-dependent DNA methylase, indicating that all AdoMet methylases may have a common structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_8127373}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8127373 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8127373}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Neurotransmitter degradation]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:33:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:39:21 2008''