1v9f: Difference between revisions

Revision as of 02:36, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1v9f.png

Template:STRUCTURE 1v9f

Crystal structure of catalytic domain of pseudouridine synthase RluD from Escherichia coliCrystal structure of catalytic domain of pseudouridine synthase RluD from Escherichia coli

Template:ABSTRACT PUBMED 15078091

About this StructureAbout this Structure

1V9F is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli., Mizutani K, Machida Y, Unzai S, Park SY, Tame JR, Biochemistry. 2004 Apr 20;43(15):4454-63. PMID:15078091

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OCA

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-'''Crystal structure of catalytic domain of pseudouridine synthase RluD from Escherichia coli'''
+===Crystal structure of catalytic domain of pseudouridine synthase RluD from Escherichia coli===
-==Overview==
+<!--
-The most frequent modification of RNA, the conversion of uridine bases to pseudouridines, is found in all living organisms and often in highly conserved locations in ribosomal and transfer RNA. RluC and RluD are homologous enzymes which each convert three specific uridine bases in Escherichia coli ribosomal 23S RNA to pseudouridine: bases 955, 2504, and 2580 in the case of RluC and 1911, 1915, and 1917 in the case of RluD. Both have an N-terminal S4 RNA binding domain. While the loss of RluC has little phenotypic effect, loss of RluD results in a much reduced growth rate. We have determined the crystal structures of the catalytic domain of RluC, and full-length RluD. The S4 domain of RluD appears to be highly flexible or unfolded and is completely invisible in the electron density map. Despite the conserved topology shared by the two proteins, the surface shape and charge distribution are very different. The models suggest significant differences in substrate binding by different pseudouridine synthases.
+The line below this paragraph, {{ABSTRACT_PUBMED_15078091}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15078091}}
 ==About this Structure==
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 [[Category: Pseudouridine synthase]]
 [[Category: Rna binding]]
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