1ulf: Difference between revisions

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-[[Image:1ulf.jpg|left|200px]]
+{{Seed}}
+[[Image:1ulf.png|left|200px]]
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 {{STRUCTURE_1ulf|  PDB=1ulf  |  SCENE=  }}
-'''CGL2 in complex with Blood Group A tetrasaccharide'''
+===CGL2 in complex with Blood Group A tetrasaccharide===
-==Overview==
+<!--
-Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.
+The line below this paragraph, {{ABSTRACT_PUBMED_15062091}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15062091 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15062091}}
 ==About this Structure==
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 [[Category: Lectin]]
 [[Category: Sugar binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:23:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:41:27 2008''