1xud: Difference between revisions
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New page: left|200px<br /> <applet load="1xud" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xud, resolution 1.800Å" /> '''Matrix metalloprot... |
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[[Image:1xud. | [[Image:1xud.jpg|left|200px]]<br /><applet load="1xud" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1xud" size=" | |||
caption="1xud, resolution 1.800Å" /> | caption="1xud, resolution 1.800Å" /> | ||
'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''<br /> | '''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1XUD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA and PB4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1XUD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=PB4:'>PB4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: non-zinc binding inhibitor]] | [[Category: non-zinc binding inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:10:32 2008'' | ||
Revision as of 18:10, 15 February 2008
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Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor
OverviewOverview
The paradigm for matrix metalloprotease inhibition combines active site, tailoring and catalytic zinc ligation. But, selectivity has been, difficult. Now, Engel et al. present novel compounds, completely selective, for MMP-13, with a unique binding mode.
About this StructureAbout this Structure
1XUD is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640
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