1xks: Difference between revisions
New page: left|200px<br /> <applet load="1xks" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xks, resolution 2.35Å" /> '''The crystal structu... |
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[[Image:1xks.gif|left|200px]]<br /> | [[Image:1xks.gif|left|200px]]<br /><applet load="1xks" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1xks, resolution 2.35Å" /> | caption="1xks, resolution 2.35Å" /> | ||
'''The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins'''<br /> | '''The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins'''<br /> | ||
==Overview== | ==Overview== | ||
Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) | Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) whose complex architecture is generated from a set of only approximately 30 proteins, termed nucleoporins. Here, we explore the domain structure of Nup133, a nucleoporin in a conserved NPC subcomplex that is crucial for NPC biogenesis and is believed to form part of the NPC scaffold. We show that human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed beta-propeller. The surface properties and conservation of the Nup133 beta-propeller suggest it may mediate multiple interactions with other proteins. Other beta-propellers are predicted in a third of all nucleoporins. These and several other repeat-based motifs appear to be major elements of nucleoporins, indicating a level of structural repetition that may conceptually simplify the assembly and disassembly of this huge protein complex. | ||
==About this Structure== | ==About this Structure== | ||
1XKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1XKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Berke, I | [[Category: Berke, I C.]] | ||
[[Category: Blobel, G.]] | [[Category: Blobel, G.]] | ||
[[Category: Boehmer, T.]] | [[Category: Boehmer, T.]] | ||
[[Category: Schwartz, T | [[Category: Schwartz, T U.]] | ||
[[Category: beta-propeller]] | [[Category: beta-propeller]] | ||
[[Category: helical insertions]] | [[Category: helical insertions]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:55:50 2008'' | ||
