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| {{STRUCTURE_1u0s| PDB=1u0s | SCENE= }} | | {{STRUCTURE_1u0s| PDB=1u0s | SCENE= }} |
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| '''Chemotaxis kinase CheA P2 domain in complex with response regulator CheY from the thermophile thermotoga maritima'''
| | ===Chemotaxis kinase CheA P2 domain in complex with response regulator CheY from the thermophile thermotoga maritima=== |
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| ==Overview==
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| Although interfaces mediating protein-protein interactions are thought to be under strong evolutionary constraints, binding of the chemotaxis histidine kinase CheA to its phosphorylation target CheY suggests otherwise. The structure of Thermotoga maritima CheA domain P2 in complex with CheY reveals a different association than that observed for the same Escherichia coli proteins. Similar regions of CheY bind CheA P2 in the two systems, but the CheA P2 domains differ by an approximately 90 degrees rotation. CheA binds CheY with identical affinity in T. maritima and E. coli at the vastly different temperatures where the respective organisms live. Distinct sets of P2 residues mediate CheY binding in the two complexes; conservation patterns of these residues in CheA and compensations in CheY delineate two families of prokaryotic chemotaxis systems. A protein complex that has the same components and general function in different organisms, but an altered structure, indicates unanticipated complexity in the evolution of protein-protein interactions and cautions against extrapolating structural data from homologs.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15289606}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15289606 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15289606}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Transient complex of thermostable protein]] | | [[Category: Transient complex of thermostable protein]] |
| [[Category: Transient interaction]] | | [[Category: Transient interaction]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:36:40 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:02:13 2008'' |