1tzn: Difference between revisions

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-[[Image:1tzn.gif|left|200px]]
+{{Seed}}
+[[Image:1tzn.png|left|200px]]
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 {{STRUCTURE_1tzn|  PDB=1tzn  |  SCENE=  }}
-'''Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor'''
+===Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor===
-==Overview==
+<!--
-After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later undergoes pH-dependent conversion to a pore, mediating translocation of the edema and lethal factors to the cytosol. We describe structures of the prepore (3.6 A) and a prepore:receptor complex (4.3 A) that reveal the location of pore-forming loops and an unexpected interaction of the receptor with the pore-forming domain. Lower pH is required for prepore-to-pore conversion in the presence of the receptor, indicating that this interaction regulates pH-dependent pore formation. We present an example of a receptor negatively regulating pH-dependent membrane insertion.
+The line below this paragraph, {{ABSTRACT_PUBMED_15326297}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15326297 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15326297}}
 ==Disease==
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 [[Category: Wigelsworth, D J.]]
 [[Category: Heptamer]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:33:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:37:04 2008''