1tty: Difference between revisions

Revision as of 19:50, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1tty.png

Template:STRUCTURE 1tty

Solution structure of sigma A region 4 from Thermotoga maritimaSolution structure of sigma A region 4 from Thermotoga maritima

Template:ABSTRACT PUBMED 15257291

About this StructureAbout this Structure

1TTY is a Single protein structure of sequence from Thermotoga maritima. Full experimental information is available from OCA.

ReferenceReference

T4 AsiA blocks DNA recognition by remodeling sigma70 region 4., Lambert LJ, Wei Y, Schirf V, Demeler B, Werner MH, EMBO J. 2004 Aug 4;23(15):2952-62. Epub 2004 Jul 15. PMID:15257291

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-[[Image:1tty.gif|left|200px]]
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 {{STRUCTURE_1tty|  PDB=1tty  |  SCENE=  }}
-'''Solution structure of sigma A region 4 from Thermotoga maritima'''
+===Solution structure of sigma A region 4 from Thermotoga maritima===
-==Overview==
+<!--
-Bacteriophage T4 AsiA is a versatile transcription factor capable of inhibiting host gene expression as an 'anti-sigma' factor while simultaneously promoting gene-specific expression of T4 middle genes in conjunction with T4 MotA. To accomplish this task, AsiA engages conserved region 4 of Eschericia coli sigma70, blocking recognition of most host promoters by sequestering the DNA-binding surface at the AsiA/sigma70 interface. The three-dimensional structure of an AsiA/region 4 complex reveals that the C-terminal alpha helix of region 4 is unstructured, while four other helices adopt a completely different conformation relative to the canonical structure of unbound region 4. That AsiA induces, rather than merely stabilizes, this rearrangement can be realized by comparison to the homologous structures of region 4 solved in a variety of contexts, including the structure of Thermotoga maritima sigmaA region 4 described herein. AsiA simultaneously occupies the surface of region 4 that ordinarily contacts core RNA polymerase (RNAP), suggesting that an AsiA-bound sigma70 may also undergo conformational changes in the context of the RNAP holoenzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_15257291}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15257291 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15257291}}
 ==About this Structure==
-TTY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTY OCA].
+TTY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTY OCA].
 ==Reference==
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 [[Category: Rna polymerase]]
 [[Category: Sigma factor]]
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