1tnp: Difference between revisions

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{{STRUCTURE_1tnp|  PDB=1tnp  |  SCENE=  }}  
{{STRUCTURE_1tnp|  PDB=1tnp  |  SCENE=  }}  


'''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH'''
===STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH===




==Overview==
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Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction.
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{{ABSTRACT_PUBMED_7552750}}


==About this Structure==
==About this Structure==
1TNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TNP OCA].  
1TNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TNP OCA].  


==Reference==
==Reference==
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[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:29:41 2008''

Revision as of 16:29, 29 July 2008

File:1tnp.png

Template:STRUCTURE 1tnp

STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCHSTRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH

Template:ABSTRACT PUBMED 7552750

About this StructureAbout this Structure

1TNP is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

ReferenceReference

Structures of the troponin C regulatory domains in the apo and calcium-saturated states., Gagne SM, Tsuda S, Li MX, Smillie LB, Sykes BD, Nat Struct Biol. 1995 Sep;2(9):784-9. PMID:7552750

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