Fibroblast growth factor receptor: Difference between revisions
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'''Fibroblast growth factor receptors''' (FGFR) are receptors which bind [[fibroblast growth factors]] (FGF). Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation<ref>PMID:8713482</ref>. See also [[Receptor tyrosine kinases]] and [[Kinase-linked, enzyme-linked and related receptors]]. | '''Fibroblast growth factor receptors''' (FGFR) are receptors which bind [[fibroblast growth factors]] (FGF). Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation<ref>PMID:8713482</ref>. See also [[Receptor tyrosine kinases]] and [[Kinase-linked, enzyme-linked and related receptors]]. | ||
*'''FGFR2''' is essential for limb induction<ref>PMID:9435295</ref>. | *'''FGFR2''' is essential for limb induction<ref>PMID:9435295</ref>. | ||
*'''FGFR3''' is involved in skeletal dysplasia<ref>PMID:22045636</ref>. | |||
== Disease == | == Disease == | ||