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| [[Image:1tb6.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1tb6| PDB=1tb6 | SCENE= }} | | {{STRUCTURE_1tb6| PDB=1tb6 | SCENE= }} |
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| '''2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex'''
| | ===2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex=== |
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| ==Overview==
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| The maintenance of normal blood flow depends completely on the inhibition of thrombin by antithrombin, a member of the serpin family. Antithrombin circulates at a high concentration, but only becomes capable of efficient thrombin inhibition on interaction with heparin or related glycosaminoglycans. The anticoagulant properties of therapeutic heparin are mediated by its interaction with antithrombin, although the structural basis for this interaction is unclear. Here we present the crystal structure at a resolution of 2.5 A of the ternary complex between antithrombin, thrombin and a heparin mimetic (SR123781). The structure reveals a template mechanism with antithrombin and thrombin bound to the same heparin chain. A notably close contact interface, comprised of extensive active site and exosite interactions, explains, in molecular detail, the basis of the antithrombotic properties of therapeutic heparin. | | The line below this paragraph, {{ABSTRACT_PUBMED_15311269}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15311269 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15311269}} |
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| ==Disease== | | ==Disease== |
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| [[Category: Li, W.]] | | [[Category: Li, W.]] |
| [[Category: Heparin]] | | [[Category: Heparin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:45:31 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:09:42 2008'' |