Bromodomain-containing protein: Difference between revisions
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'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>. | '''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>. | ||
*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>. | *'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>. | ||
*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>. | |||
For detalis on BRD3 see [[Human bromodomain containing protein 3]] | For detalis on BRD3 see [[Human bromodomain containing protein 3]] | ||