1shw: Difference between revisions

Revision as of 04:18, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1shw.png

Template:STRUCTURE 1shw

EphB2 / EphrinA5 Complex StructureEphB2 / EphrinA5 Complex Structure

Template:ABSTRACT PUBMED 15107857

About this StructureAbout this Structure

1SHW is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling., Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB, Nat Neurosci. 2004 May;7(5):501-9. Epub 2004 Apr 25. PMID:15107857

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OCA

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-'''EphB2 / EphrinA5 Complex Structure'''
+===EphB2 / EphrinA5 Complex Structure===
-==Overview==
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-The interactions between Eph receptor tyrosine kinases and their ephrin ligands regulate cell migration and axon pathfinding. The EphA receptors are generally thought to become activated by ephrin-A ligands, whereas the EphB receptors interact with ephrin-B ligands. Here we show that two of the most widely studied of these molecules, EphB2 and ephrin-A5, which have never been described to interact with each other, do in fact bind one another with high affinity. Exposure of EphB2-expressing cells to ephrin-A5 leads to receptor clustering, autophosphorylation and initiation of downstream signaling. Ephrin-A5 induces EphB2-mediated growth cone collapse and neurite retraction in a model system. We further show, using X-ray crystallography, that the ephrin-A5-EphB2 complex is a heterodimer and is architecturally distinct from the tetrameric EphB2-ephrin-B2 structure. The structural data reveal the molecular basis for EphB2-ephrin-A5 signaling and provide a framework for understanding the complexities of functional interactions and crosstalk between A- and B-subclass Eph receptors and ephrins.
+The line below this paragraph, {{ABSTRACT_PUBMED_15107857}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Ephrin signaling]]
 [[Category: Receptor tyrosine kinase]]
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