8v9r: Difference between revisions

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'''Unreleased structure'''


The entry 8v9r is ON HOLD  until Paper Publication
==Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTX==
 
<StructureSection load='8v9r' size='340' side='right'caption='[[8v9r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Ghanbarpour, A., Sauer, R.T., Davis, J.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8v9r]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Paracoccus Paracoccus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V9R FirstGlance]. <br>
Description: Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a DHFR-ssrA Protein Substrate
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>
[[Category: Ghanbarpour, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v9r OCA], [https://pdbe.org/8v9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v9r RCSB], [https://www.ebi.ac.uk/pdbsum/8v9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v9r ProSAT]</span></td></tr>
[[Category: Sauer, R.T]]
</table>
[[Category: Davis, J.H]]
== Function ==
[https://www.uniprot.org/uniprot/CLPX_ECOLI CLPX_ECOLI] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Paracoccus]]
[[Category: Davis JH]]
[[Category: Ghanbarpour A]]
[[Category: Sauer RT]]

Latest revision as of 07:14, 17 October 2024

Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTXCryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTX

Structural highlights

8v9r is a 21 chain structure with sequence from Escherichia coli and Paracoccus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 2.8Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CLPX_ECOLI ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175]

8v9r, resolution 2.80Å

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OCA
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