1s68: Difference between revisions

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-[[Image:1s68.jpg|left|200px]]
+{{Seed}}
+[[Image:1s68.png|left|200px]]
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 {{STRUCTURE_1s68|  PDB=1s68  |  SCENE=  }}
-'''Structure and Mechanism of RNA Ligase'''
+===Structure and Mechanism of RNA Ligase===
-==Overview==
+<!--
-T4 RNA ligase 2 (Rnl2) exemplifies an RNA ligase family that includes the RNA editing ligases (RELs) of Trypanosoma and Leishmania. The Rnl2/REL enzymes are defined by essential signature residues and a unique C-terminal domain, which we show is essential for sealing of 3'-OH and 5'-PO4 RNA ends by Rnl2, but not for ligase adenylation or phosphodiester bond formation at a preadenylated AppRNA end. The N-terminal segment Rnl2(1-249) of the 334 aa Rnl2 protein comprises an autonomous adenylyltransferase/AppRNA ligase domain. We report the 1.9 A crystal structure of the ligase domain with AMP bound at the active site, which reveals a shared fold, catalytic mechanism, and evolutionary history for RNA ligases, DNA ligases, and mRNA capping enzymes.
+The line below this paragraph, {{ABSTRACT_PUBMED_14962393}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14962393 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_14962393}}
 ==About this Structure==
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 [[Category: Rna repair]]
 [[Category: T4]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:21:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:27:17 2008''