1ryx: Difference between revisions

Revision as of 13:27, 28 July 2008

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File:1ryx.png

Template:STRUCTURE 1ryx

Crystal structure of hen serum transferrin in apo- formCrystal structure of hen serum transferrin in apo- form

Template:ABSTRACT PUBMED 15044101

About this StructureAbout this Structure

1RYX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

ReferenceReference

Tertiary structural changes associated with iron binding and release in hen serum transferrin: a crystallographic and spectroscopic study., Thakurta PG, Choudhury D, Dasgupta R, Dattagupta JK, Biochem Biophys Res Commun. 2004 Apr 16;316(4):1124-31. PMID:15044101

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OCA

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-'''Crystal structure of hen serum transferrin in apo- form'''
+===Crystal structure of hen serum transferrin in apo- form===
-==Overview==
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-The iron binding and release of serum transferrin are pH-dependent and accompanied by a conformational change between the iron-bound (holo-) and iron-free (apo-) forms. We have determined the crystal structure of apo-hen serum transferrin (hAST) at 3.5A resolution, which is the first reported structure to date of any full molecule of an apo-serum transferrin and studied its pH-dependent iron release by UV-vis absorption and near UV-CD spectroscopy. The crystal structure of hAST shows that both the lobes adopt an open conformation and the relative orientations of the domains are different from those of apo-human serum transferrin and human apolactoferrin but similar to that of hen apo-ovotransferrin. Spectroscopic analysis reveals that in hen serum transferrin, release of the first iron starts at a pH approximately 6.5 and continues over a broad pH range (6.5-5.2). The complete release of the iron, however, occurs at pH approximately 4.0. The near UV-CD spectra show alterations in the microenvironment of the aromatic residues surrounding the iron-binding sites.
+The line below this paragraph, {{ABSTRACT_PUBMED_15044101}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Domain orientation]]
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