Basigin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
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== Function == | == Function == | ||
'''Basigin''' or '''CD147''' or '''EMMORIN''' is a transmembranal glycoprotein which is a receptor for a variety of proteins<ref>PMID:26684586</ref>. Basigin has several isoforms and contains immunoglobulin domains. | '''Basigin''' or '''CD147''' or '''EMMORIN''' is a transmembranal glycoprotein which is a receptor for a variety of proteins and is expressed by tumor cells<ref>PMID:26684586</ref>. Basigin has several isoforms and contains immunoglobulin-like domains (Ig-like). Alternative splicing of basigin results in 4 different isoforms. Basigin-2 is the most predominant form and contains 2 Ig-like domains. Basigin-1 contains 3 Ig-like domains, basigin-3 contains 1 Ig-like domain<ref>PMID:21536654</ref>. | ||
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders<ref>PMID:35844594</ref>. | Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders<ref>PMID:35844594</ref>. Hence, basigin has been termed a cancer-associated biomarker and serves as a target for cancer therapy. | ||
== Structural highlights == | == Structural highlights == | ||