Sandbox Ben Whiteside: Difference between revisions
No edit summary |
No edit summary |
||
| Line 11: | Line 11: | ||
[https://en.wikipedia.org/wiki/Amylin Amylin Peptide] | [https://en.wikipedia.org/wiki/Amylin Amylin Peptide] | ||
== Structure == | == Structure == | ||
<scene name='10/1038828/Entire_protein_scene/3'> | The <scene name='10/1038828/Entire_protein_scene/3'>amylin g-protein coupled receptor</scene> is a heterodimeric protein containing a calcitonin receptor domain, as well as one of three receptor activity modifying proteins. During feeding, cells in the body will secrete the ligand, amylin. Amylin is a 37 amino acid glucoregulatory hormone that is produced within beta cells of the pancreas. When there is an influx of nutrients in the gastrointestinal tract, the ligand will bind to the heterodimeric receptor, activating the receptor and triggering the corresponding signaling cascade. The overall effect of this cascade is increased satiety, delayed gastric emptying, and inhibition of glucagon secretion. | ||
=== Transmembrane Domain === | === Transmembrane Domain === | ||
<scene name='10/1038828/Tmd_interactions_with_the_plb/5'>Hydrophoic R groups within the transmembrane domain</scene> | <scene name='10/1038828/Tmd_interactions_with_the_plb/5'>Hydrophoic R groups within the transmembrane domain</scene> | ||