1qxp: Difference between revisions

Revision as of 08:07, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1qxp.png

Template:STRUCTURE 1qxp

Crystal Structure of a mu-like calpainCrystal Structure of a mu-like calpain

Template:ABSTRACT PUBMED 14656436

About this StructureAbout this Structure

1QXP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement., Pal GP, De Veyra T, Elce JS, Jia Z, Structure. 2003 Dec;11(12):1521-6. PMID:14656436

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of a mu-like calpain'''
+===Crystal Structure of a mu-like calpain===
-==Overview==
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-The two Ca2+-dependent cysteine proteases, micro- and m-calpain, are involved in various Ca2+-linked signal pathways but differ markedly in their Ca2+ requirements for activation. We have determined the structure of a micro-like calpain, which has 85% micro-calpain sequence (the first 48 and the last 62 residues of the large subunit are those from m-calpain) and a low Ca2+ requirement. This construct was used because micro-calpain itself is too poorly expressed. The structure of micro-like calpain is very similar in overall fold to that of m-calpain as expected, but differs significantly in two aspects. In comparison with m-calpain, the catalytic triad residues in micro-like calpain, His and Cys, are much closer together in the absence of Ca2+, and significant portions of the Ca2+ binding EF-hand motifs are disordered and more flexible. These structural differences imply that Ca2+-free micro-calpain may represent a partially activated structure, requiring lower Ca2+ concentration to trigger its activation.
+The line below this paragraph, {{ABSTRACT_PUBMED_14656436}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14656436 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_14656436}}
 ==About this Structure==
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 [[Category: M-calpain]]
 [[Category: Mu-calpain]]
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