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| [[Image:1qhv.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1qhv| PDB=1qhv | SCENE= }} | | {{STRUCTURE_1qhv| PDB=1qhv | SCENE= }} |
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| '''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD'''
| | ===HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD=== |
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| ==Overview==
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| Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10502512}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10502512 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10502512}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Extra-ordinary stability]] | | [[Category: Extra-ordinary stability]] |
| [[Category: Receptor binding]] | | [[Category: Receptor binding]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:17:32 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:21:28 2008'' |