1qh2: Difference between revisions

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[[Image:1qh2.jpg|left|200px]]
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{{STRUCTURE_1qh2|  PDB=1qh2  |  SCENE=  }}  
{{STRUCTURE_1qh2|  PDB=1qh2  |  SCENE=  }}  


'''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''
===CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA===




==Overview==
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Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
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{{ABSTRACT_PUBMED_10360353}}


==About this Structure==
==About this Structure==
1QH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].  
1QH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].  


==Reference==
==Reference==
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[[Category: Potato ii trypsin inhibitor]]
[[Category: Potato ii trypsin inhibitor]]
[[Category: Serine proteinase inhibitor]]
[[Category: Serine proteinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:02 2008''

Revision as of 08:07, 28 July 2008

File:1qh2.png

Template:STRUCTURE 1qh2

CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATACHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA

Template:ABSTRACT PUBMED 10360353

About this StructureAbout this Structure

1QH2 is a Protein complex structure of sequences from Nicotiana alata. Full experimental information is available from OCA.

ReferenceReference

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein., Lee MC, Scanlon MJ, Craik DJ, Anderson MA, Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353

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