1qcf: Difference between revisions

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-[[Image:1qcf.gif|left|200px]]
+{{Seed}}
+[[Image:1qcf.png|left|200px]]
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 {{STRUCTURE_1qcf|  PDB=1qcf  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR'''
+===CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR===
-==Overview==
+<!--
-The crystal structure of the autoinhibited form of Hck has been determined at 2.0 A resolution, in complex with a specific pyrazolo pyrimidine-type inhibitor, PP1. The activation segment, a key regulatory component of the catalytic domain, is unphosphorylated and is visualized in its entirety. Tyr-416, the site of activating autophosphorylation in the Src family kinases, is positioned such that access to the catalytic machinery is blocked. PP1 is bound at the ATP-binding site of the kinase, and a methylphenyl group on PP1 is inserted into an adjacent hydrophobic pocket. The enlargement of this pocket in autoinhibited Src kinases suggests a route toward the development of inhibitors that are specific for the inactive forms of these proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_10360180}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10360180 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10360180}}
 ==About this Structure==
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 [[Category: Ordered activation loop]]
 [[Category: Tyrosine kinase-inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:07:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:39:18 2008''