1q06: Difference between revisions

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-[[Image:1q06.gif|left|200px]]
+{{Seed}}
+[[Image:1q06.png|left|200px]]
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 {{STRUCTURE_1q06|  PDB=1q06  |  SCENE=  }}
-'''Crystal structure of the Ag(I) form of E. coli CueR, a copper efflux regulator'''
+===Crystal structure of the Ag(I) form of E. coli CueR, a copper efflux regulator===
-==Overview==
+<!--
-The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
+The line below this paragraph, {{ABSTRACT_PUBMED_12958362}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12958362 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12958362}}
 ==About this Structure==
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 [[Category: Copper efflux regulator]]
 [[Category: Merr family transcriptional regulator]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:42:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:55:12 2008''