1p9c: Difference between revisions

Revision as of 11:50, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1p9c.png

Template:STRUCTURE 1p9c

NMR solution structure of the C-terminal ubiquitin-interacting motif of the proteasome subunit S5aNMR solution structure of the C-terminal ubiquitin-interacting motif of the proteasome subunit S5a

Template:ABSTRACT PUBMED 12970176

About this StructureAbout this Structure

1P9C is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Structural determinants for the binding of ubiquitin-like domains to the proteasome., Mueller TD, Feigon J, EMBO J. 2003 Sep 15;22(18):4634-45. PMID:12970176

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OCA

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-[[Image:1p9c.gif|left|200px]]
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 {{STRUCTURE_1p9c|  PDB=1p9c  |  SCENE=  }}
-'''NMR solution structure of the C-terminal ubiquitin-interacting motif of the proteasome subunit S5a'''
+===NMR solution structure of the C-terminal ubiquitin-interacting motif of the proteasome subunit S5a===
-==Overview==
+<!--
-HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting a role in the ubiquitin-proteasome pathway as well. The Ubl domain binds with high affinity to the second ubiquitin-interacting motif (UIM) of the S5a subunit of the proteasome. Here we present the solution structures of the HHR23A Ubl domain, the second UIM of S5a (UIM-2), and the Ubl:S5a-UIM-2 complex. The HHR23A Ubl domain is structurally similar to ubiquitin. The S5a UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface with Ubl. The molecular determinants of the Ubl-proteasome interaction are revealed by analysis of the structures, chemical shift mapping, mutant binding studies and sequence conservation.
+The line below this paragraph, {{ABSTRACT_PUBMED_12970176}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12970176 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12970176}}
 ==About this Structure==
-P9C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9C OCA].
+P9C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9C OCA].
 ==Reference==
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 [[Category: Alpha helix]]
 [[Category: Hairpin loop]]
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