1oy6: Difference between revisions

Revision as of 08:14, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1oy6.png

Template:STRUCTURE 1oy6

Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux PumpStructural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump

Template:ABSTRACT PUBMED 12738864

About this StructureAbout this Structure

1OY6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump., Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr, Science. 2003 May 9;300(5621):976-80. PMID:12738864

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OCA

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-==Overview==
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-Multidrug efflux pumps cause serious problems in cancer chemotherapy and treatment of bacterial infections. Yet high-resolution structures of ligand transporter complexes have previously been unavailable. We obtained x-ray crystallographic structures of the trimeric AcrB pump from Escherichia coli with four structurally diverse ligands. The structures show that three molecules of ligands bind simultaneously to the extremely large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions. Each ligand uses a slightly different subset of AcrB residues for binding. The bound ligand molecules often interact with each other, stabilizing the binding.
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 [[Category: Zgurskaya, H I.]]
 [[Category: Membrane protein]]
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