1oxa: Difference between revisions

Revision as of 05:13, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1oxa.png

Template:STRUCTURE 1oxa

CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)

Template:ABSTRACT PUBMED 7749919

About this StructureAbout this Structure

1OXA is a Single protein structure of sequence from Saccharopolyspora erythraea. Full crystallographic information is available from OCA.

ReferenceReference

Structure of cytochrome P450eryF involved in erythromycin biosynthesis., Cupp-Vickery JR, Poulos TL, Nat Struct Biol. 1995 Feb;2(2):144-53. PMID:7749919

Page seeded by OCA on Mon Jul 28 05:13:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)'''
+===CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)===
-==Overview==
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-Cytochrome P450eryF catalyzes the 6S-hydroxylation of 6-deoxyerythronolide B, the initial reaction in a multistep pathway to convert 6-deoxyerythronolide B into the antibiotic, erythromycin. The overall structure of P450eryF is similar to that of P450cam but differs in the exact positioning of several alpha-helices. The largest difference occurs in the B' helix and results in the enlargement of the substrate-binding pocket of P450eryF. The substrate is positioned with the macrolide ring perpendicular to the haem plane and contacts seven hydrophobic residues and three solvent molecules. The substrate participates in a network of hydrogen bonds that may provide a proton shuttle pathway in the oxygen cleavage reaction.
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 ==About this Structure==
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 [[Category: Cupp-Vickery, J R.]]
 [[Category: Poulos, T L.]]
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