1orp: Difference between revisions

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-[[Image:1orp.gif|left|200px]]
+{{Seed}}
+[[Image:1orp.png|left|200px]]
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 {{STRUCTURE_1orp|  PDB=1orp  |  SCENE=  }}
-'''Structure of a Trapped Endonuclease III-DNA Covalent Intermediate: Estranged-Adenine Complex'''
+===Structure of a Trapped Endonuclease III-DNA Covalent Intermediate: Estranged-Adenine Complex===
-==Overview==
+<!--
-Nearly all cells express proteins that confer resistance to the mutagenic effects of oxidative DNA damage. The primary defense against the toxicity of oxidative nucleobase lesions in DNA is the base-excision repair (BER) pathway. Endonuclease III (EndoIII) is a [4Fe-4S] cluster-containing DNA glycosylase with repair activity specific for oxidized pyrimidine lesions in duplex DNA. We have determined the crystal structure of a trapped intermediate that represents EndoIII frozen in the act of repairing DNA. The structure of the protein-DNA complex provides insight into the ability of EndoIII to recognize and repair a diverse array of oxidatively damaged bases. This structure also suggests a rationale for the frequent occurrence in certain human cancers of a specific mutation in the related DNA repair protein MYH.
+The line below this paragraph, {{ABSTRACT_PUBMED_12840008}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12840008 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12840008}}
 ==About this Structure==
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 [[Category: Dna repair]]
 [[Category: Iron-sulfur cluster]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:12:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:43:51 2008''