1psi: Difference between revisions
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caption="1psi, resolution 2.92Å" /> | caption="1psi, resolution 2.92Å" /> | ||
'''INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU'''<br /> | '''INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU'''<br /> | ||
==Overview== | ==Overview== | ||
The reactive site loop of the serpin family of serine proteinase | The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the loop in a stable canonical conformation matching that found in all other families of serine proteinase inhibitors. This unexpected finding in the absence of loop insertion into the body of the molecule favours a two-stage mechanism of inhibition and provides a model for the heparin activation of antithrombin. The beta-pleated strand conformation of the loop also accounts for the polymerization of the serpins in disease and for their association with other beta-sheet structures, most notably the beta-amyloid of Alzheimer's disease. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1PSI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SCC as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1PSI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb53_1.html Serpins]]. Full crystallographic information is available from [http:// | 1PSI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SCC:'>SCC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1PSI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb53_1.html Serpins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSI OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Serpins]] | [[Category: Serpins]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abrahams, J | [[Category: Abrahams, J P.]] | ||
[[Category: Carrell, R | [[Category: Carrell, R W.]] | ||
[[Category: Elliott, P | [[Category: Elliott, P R.]] | ||
[[Category: Lomas, D | [[Category: Lomas, D A.]] | ||
[[Category: SCC]] | [[Category: SCC]] | ||
[[Category: acute phase]] | [[Category: acute phase]] | ||
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[[Category: signal]] | [[Category: signal]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:32:07 2008'' | ||
Revision as of 15:32, 21 February 2008
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INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU
OverviewOverview
The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the loop in a stable canonical conformation matching that found in all other families of serine proteinase inhibitors. This unexpected finding in the absence of loop insertion into the body of the molecule favours a two-stage mechanism of inhibition and provides a model for the heparin activation of antithrombin. The beta-pleated strand conformation of the loop also accounts for the polymerization of the serpins in disease and for their association with other beta-sheet structures, most notably the beta-amyloid of Alzheimer's disease.
DiseaseDisease
Known diseases associated with this structure: Emphysema OMIM:[107400], Emphysema-cirrhosis OMIM:[107400], Hemorrhagic diathesis due to antithrombin Pittsburgh OMIM:[107400], Pulmonary disease, chronic obstructive, susceptibility to OMIM:[107400]
About this StructureAbout this Structure
1PSI is a Single protein structure of sequence from Homo sapiens with as ligand. The following page contains interesting information on the relation of 1PSI with [Serpins]. Full crystallographic information is available from OCA.
ReferenceReference
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin., Elliott PR, Lomas DA, Carrell RW, Abrahams JP, Nat Struct Biol. 1996 Aug;3(8):676-81. PMID:8756325
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