8bpi: Difference between revisions
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<table><tr><td colspan='2'>[[8bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPI FirstGlance]. <br> | <table><tr><td colspan='2'>[[8bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPI FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpi OCA], [https://pdbe.org/8bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpi RCSB], [https://www.ebi.ac.uk/pdbsum/8bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpi ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpi OCA], [https://pdbe.org/8bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpi RCSB], [https://www.ebi.ac.uk/pdbsum/8bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpi ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CRGD_HUMAN CRGD_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens. | [https://www.uniprot.org/uniprot/CRGD_HUMAN CRGD_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens. | ||
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== Publication Abstract from PubMed == | |||
Human gamma-D crystallin (HGD) is a major constituent of the eye lens. Aggregation of HGD contributes to cataract formation, the leading cause of blindness worldwide. It is unique in its longevity, maintaining its folded and soluble state for 50-60 years. One outstanding question is the structural basis of this longevity despite oxidative aging and environmental stressors including ultraviolet radiation (UV). Here we present crystallographic structures evidencing a UV-induced crystallin redox switch mechanism. The room-temperature serial synchrotron crystallographic (SSX) structure of freshly prepared crystallin mutant (R36S) shows no post-translational modifications. After aging for nine months in the absence of light, a thiol-adduct (dithiothreitol) modifying surface cysteines is observed by low-dose SSX. This is shown to be UV-labile in an acutely light-exposed structure. This suggests a mechanism by which a major source of crystallin damage, UV, may also act as a rescuing factor in a finely balanced redox system. | |||
An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin.,Hill JA, Nyathi Y, Horrell S, von Stetten D, Axford D, Owen RL, Beddard GS, Pearson AR, Ginn HM, Yorke BA Commun Chem. 2024 Apr 10;7(1):81. doi: 10.1038/s42004-024-01163-w. PMID:38600176<ref>PMID:38600176</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | == References == | ||
<references/> | <references/> | ||