8wo2: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8wo2 is ON HOLD  until Paper Publication
+==Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val-AMP==
+<StructureSection load='8wo2' size='340' side='right'caption='[[8wo2]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
-Authors: Guo, Y., Li, S., Zhang, T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8wo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WO2 FirstGlance]. <br>
-Description: Crystal structures of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val-AMP
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WN9:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+(2S)-2-azanyl-3-methyl-butanoate'>WN9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Li, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wo2 OCA], [https://pdbe.org/8wo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wo2 RCSB], [https://www.ebi.ac.uk/pdbsum/8wo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wo2 ProSAT]</span></td></tr>
-[[Category: Zhang, T]]
+</table>
-[[Category: Guo, Y]]
+== Function ==
+[https://www.uniprot.org/uniprot/A0A2J9KLI1_HELPX A0A2J9KLI1_HELPX] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).[ARBA:ARBA00025217][HAMAP-Rule:MF_02002]
+__TOC__
+</StructureSection>
+[[Category: Helicobacter pylori]]
+[[Category: Large Structures]]
+[[Category: Guo Y]]
+[[Category: Li S]]
+[[Category: Zhang T]]