Base pairing: Difference between revisions
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
Historically, it was difficult to provide structural evidence of base pairing without solving the structure of a DNA helix fragments of ten or more base pairs. The first crystal structure of a base pair was solved by Hoogsteen in 1963 <ref>DOI:10.1107/S0365110X63002437</ref> and was not canonical (it is called a Hoogsteen pair now). A theoretical analysis of possible base pairs was difficult because the lowest energy tautomers of bases were unknown or disputed, making it impossible to distinguish possible hydrogen bond donors and acceptors. | Historically, it was difficult to provide structural evidence of base pairing without solving the structure of a DNA helix fragments of ten or more base pairs. The first crystal structure of a base pair was solved by Hoogsteen in 1963 <ref>DOI:10.1107/S0365110X63002437</ref> and was not canonical (it is called a Hoogsteen pair now). A theoretical analysis of possible base pairs was difficult because the lowest energy tautomers of bases were unknown or disputed, making it impossible to distinguish possible hydrogen bond donors and acceptors. | ||
<scene name='10/1009519/Rna_triplex/1'>RNA structures</scene> frequently contain non-canonical base pairs, <scene name='10/1009519/Rna_triplex/2'>base triples</scene> and base quadruplexes. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||