1o29: Difference between revisions

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-[[Image:1o29.jpg|left|200px]]
+{{Seed}}
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 {{STRUCTURE_1o29|  PDB=1o29  |  SCENE=  }}
-'''Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and FdUMP at 2.0 A resolution'''
+===Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and FdUMP at 2.0 A resolution===
-==Overview==
+<!--
-Like thymidylate synthase (TS) in eukaryotes, the thymidylate synthase-complementing proteins (TSCPs) are mandatory for cell survival of many prokaryotes in the absence of external sources of thymidylate. Details of the mechanism of this novel family of enzymes are unknown. Here, we report the structural and functional analysis of a TSCP from Thermotoga maritima and its complexes with substrate, analogs, and cofactor. The structures presented here provide a basis for rationalizing the TSCP catalysis and reveal the possibility of the design of an inhibitor. We have identified a new helix-loop-strand FAD binding motif characteristic of the enzymes in the TSCP family. The presence of a hydrophobic core with residues conserved among the TSCP family suggests a common overall fold.
+The line below this paragraph, {{ABSTRACT_PUBMED_12791256}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12791256 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12791256}}
 ==About this Structure==
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 [[Category: Thymidylate synthase complementing protein]]
 [[Category: Tm0449]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:16:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:51:52 2008''