1ow6: Difference between revisions
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'''Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase'''<br /> | '''Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1OW6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | 1OW6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OW6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: domain swapping]] | [[Category: domain swapping]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:36:38 2008'' | ||
Revision as of 17:36, 15 February 2008
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Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase
OverviewOverview
Focal adhesions (FAs) are large submembrane signaling complexes formed at, sites of cellular attachment to the extracellular matrix. The interaction, of LD motifs with their targets plays an important role in the assembly of, FAs. We have determined the molecular basis for the recognition of two, paxillin LD motifs by the FA targeting (FAT) domain of FA kinase using a, combination of X-ray crystallography, solution NMR, and homology modeling., The four-helix FAT domain displays two LD binding sites on opposite sites, of the molecule that bind LD peptides in a helical conformation. Threading, studies suggest that the LD-interacting domain of p95PKL shares a common, four-helical core with the FAT domain and the tail of vinculin, defining a, structural family of LD motif binding modules.
About this StructureAbout this Structure
1OW6 is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
ReferenceReference
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain., Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST, Structure. 2003 Oct;11(10):1207-17. PMID:14527389
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